Dr. Deepak Bhatt and Prof. Philippe Gabriel Steg discuss genotype-guided oral P2Y12-inhibition in patients with ST-segment elevation myocardial infarction undergoing primary PCI (POPular Genetics—0:50); edoxaban-based versus vitamin-K-antagonist-based anti-thrombotic regimen following successful coronary stenting in atrial fibrillation patients (ENTRUST-AF PCI—3:19); and rapid Assessment of possible ACS in the emergency department with high sensitivity troponin T (RAPID-TnT—4:41). Visit https://www.acc.org/esc2019 for full meeting coverage.