so my name is i'm sure it's
that one out the investigators and be
eyes out the ongoing decision trial
i'm i'm from the university medical center
thronging in and then we are leading
together with forty sites in the netherlands
the dye job soon evaluation in chronic
heart failure investigation or study in outpatients
in the netherlands decision trial and you
had offices about our trial which
currently ongoing as i mentioned he said
loan dollars their jobs you can effectively
reduce karate particular mortality and recurrent heart
failure hospitalizations this on top of guideline
great military fees in heart failure patients
with them
left particular ejection fraction below fifty so
in this trial we
explicitly glued at least a third of
women into to trial because in prior
heart failure trials
then there's only a minority of women
included and same holds for each of
ablation this is a trial where at
least a third it's a maximum of
two thirds of patients with a publications
that with a population are included
and so the idea is based on
the
did travel which was published there are
quite some time ago in in new
england journal of medicine in nineteen ninety
seven and in that's thirty with higher
dosage of the jokes yeah it was
demonstrated to be in there are super
controlled study to tell jokes you could
not reduced mortality and hard to
which few steps infraction fraction that he
did to reduce burgeoning heart failure or
heart failure as limitations but in such
studies of that particular trial it was
demonstrated that the low dose of the
jokes you show a concentration between point
five and point nine am
was actually beneficial all cause mortality and
the higher dosages all the jokes in
an increased mortality so did was actually
the starting point of the idea that
probably low dosages out their job she
could be beneficial to treat patients with
heart feel
yeah
and of course ever seen that it's
trial we have an
the have a lot of new drugs
and therapies that have proven to be
beneficial for patients with heart failure to
we want to investigate of course on
top of the other drugs and therapies
that are currently recommends in the guy
tries to for example we have the
ace inhibitors we have to be the
block
curse we have them race and we
add device therapy and we have to
consider our new i keep either breeding
am and after all those steps the
jokes seen is stealing the guideline for
is currently still it to be of
only and to be recommendation and by
doing this randomized controlled trial in the
netherlands aiming to include thousand the proximity
thousand patients we hope to provide the
evidence that can give a better indication
to the use of the jokes in
into the current guidelines
so at this point in time we
have already included the over four hundred
patients and we're still on track to
reach the end of the inclusion phaser
in one and a half year her
of course yeah we have also slow
down a little bit because of the
kobe pandemic but we're still very calm
for
instead to succeed with this trial and
come up with some that results in
the next few years