Rozh H. Al-Mashhadi, MD from the Aarhus University Hospital discusses Local Pressure Drives Low-Density Lipoprotein Accumulation and Coronary Atherosclerosis in Hypertensive Minipigs.
Link to Research -
https://www.jacc.org/doi/10.1016/j.jacc.2020.11.059?utm_medium=social&utm_source=twitter_post&utm_campaign=twitter_post
Instract
Context
There is a limited understanding of the mechanisms by which hypertension accelerates coronary artery disease. There are sometimes confusing humoral changes in patients with hypertension, and to date, no experimental models have allowed the isolated effect of pressure on atherosclerosis to be studied in a setting that recapitulates the dimensions and biomechanics of human coronary arteries.
Targets
This thesis aimed to examine and explore the fundamental mechanisms of the impact of pressure on coronary atherosclerosis.
Methodology
Using inflatable suprarenal aortic cuffs, in the cephalad body portion of wild-type and hypercholesterolemic proprotein convertase subtilisin kexin type 9 (PCSK9)D374Y Yucatan minipigs, we increased mean arterial pressure by >30 mm Hg for >1 year. Pressures at the caudal remained natural.
Outcomes
Cephalad hypertension accelerated coronary atherosclerosis to nearly 5-fold under hypercholesterolemic conditions in transgenic PCSK9D374Y mini pigs, with the consistent development of fibroatheromas that were sufficiently large to induce computed tomography angiography stenosis. This was caused by local pressure forces since there were no changes in lesion formation in vascular beds shielded from hypertension but subjected to the same humoral influences. The same experiment was performed to investigate the underlying mechanisms under normocholesterolemic conditions in wild-type mini-pigs. Hypertension with increased abundance of mechanical strength proteins and decreased levels of infiltrating plasma macromolecules induced clear changes in the arterial proteome. Increased smooth muscle cells and increased intimate accumulation of low-density lipoproteins in the coronary arteries were parallel to this.
Findings
Coronary atherosclerosis is facilitated by elevated pressure per se. Our data show that redesign of the artery to balance higher tensile forces in hypertension changes the movement of macromolecules and contributes to the increased intimate accumulation of lipoproteins of low density.
Hypertension
Description
Hypertension
Pensée Wu, MD, Senior Lecturer, Honorary Consultant Obstetrician and Subspecialist in Maternal Fetal Medicine Keele University. In this video, she speaks about In‐Hospital Complications in Pregnancies Conceived by Assisted Reproductive Technology.
Outline
Origins:
Infertility affects around 48 million couples worldwide, and assisted reproductive technology (ART) has emerged as a popular treatment option. Concerns about ART-related pregnancy complications have escalated as mother age has increased, as have prepregnancy cardiovascular risk factors like chronic hypertension, obesity, and diabetes. In-hospital complications associated with ART pregnancies, on the other hand, are poorly reported.
Methodology and Outcomes:
We examined hospital deliveries conceived with or without ART from the United States National Inpatient Sample database between January 1, 2008, and December 31, 2016, to identify patient characteristics, obstetric outcomes, vascular complications, and temporal trends of ART-conceived pregnancies. In our study, we included 106 248 ART-conceived pregnancies and 34 167 246 non-ART-conceived pregnancies. Women who used assisted reproductive technology (ART) were older (35 vs. 28 years; P0.0001) and had more comorbidities. Acute kidney injury: adjusted odds ratio [aOR], 2.52; 95 percent confidence interval [CI], 1.99–3.19; and arrhythmia: aOR, 1.65; 95 percent CI, 1.46–1.86) and adverse obstetric outcomes (placental abruption: aOR, 1.57; 95 percent CI, 1.41–1.74; cesarean delivery: aOR, 1.38; 95 percent CI, 1.38–1.86) were associated with ART-conceived Hospital expenditures were greater in women who did not use ART ($18 705 versus $11 983; P0.0001).
Observations:
ART-conceived pregnancies have a higher risk of poor obstetric outcomes and vascular issues when compared to spontaneous conception. Clinicians should have in-depth discussions regarding the effects of ART in women during prenatal counseling.
Pensée Wu, MD, Senior Lecturer, Honorary Consultant Obstetrician and Subspecialist in Maternal Fetal Medicine Keele University. In this video, she speaks about In‐Hospital Complications in Pregnancies Conceived by Assisted Reproductive Technology.
Outline
Origins:
Infertility affects around 48 million couples worldwide, and assisted reproductive technology (ART) has emerged as a popular treatment option. Concerns about ART-related pregnancy complications have escalated as mother age has increased, as have prepregnancy cardiovascular risk factors like chronic hypertension, obesity, and diabetes. In-hospital complications associated with ART pregnancies, on the other hand, are poorly reported.
Methodology and Outcomes:
We examined hospital deliveries conceived with or without ART from the United States National Inpatient Sample database between January 1, 2008, and December 31, 2016, to identify patient characteristics, obstetric outcomes, vascular complications, and temporal trends of ART-conceived pregnancies. In our study, we included 106 248 ART-conceived pregnancies and 34 167 246 non-ART-conceived pregnancies. Women who used assisted reproductive technology (ART) were older (35 vs. 28 years; P0.0001) and had more comorbidities. Acute kidney injury: adjusted odds ratio [aOR], 2.52; 95 percent confidence interval [CI], 1.99–3.19; and arrhythmia: aOR, 1.65; 95 percent CI, 1.46–1.86) and adverse obstetric outcomes (placental abruption: aOR, 1.57; 95 percent CI, 1.41–1.74; cesarean delivery: aOR, 1.38; 95 percent CI, 1.38–1.86) were associated with ART-conceived Hospital expenditures were greater in women who did not use ART ($18 705 versus $11 983; P0.0001).
Observations:
ART-conceived pregnancies have a higher risk of poor obstetric outcomes and vascular issues when compared to spontaneous conception. Clinicians should have in-depth discussions regarding the effects of ART in women during prenatal counseling.
Ajay J. Kirtane, MD, SM, is Professor of Medicine at Columbia University Irving Medical Center and Director of the Cardiac Catheterization Laboratories at NewYork-Presbyterian/Columbia University Irving Medical Center. Dr. Kirtane is an internationally-renowned leader in Interventional Cardiology, specializing in the care of patients with complex coronary and peripheral vascular disease. In this video, he speaks about A Study of the ReCor Medical Paradise System in Clinical Hypertension (RADIANCE-HTN).
A Summary Synopsis:
RADIANCE-HTN is a two-cohort, randomized, double-blind, sham-controlled study (TRIO and SOLO) that aims to demonstrate the efficacy and document the safety of the Paradise Renal Denervation System in two hypertensive populations.
In-depth description:
The RADIANCE Solo cohort will consist of subjects with essential hypertension who are controlled on one or two antihypertensive medications or who are uncontrolled on 0-2 antihypertensive medications, whereas the RADIANCE Trio cohort will consist of subjects with treatment resistant hypertension who are on at least three antihypertensive medications. Before randomization, subjects will be hypertensive in the absence of hypertension medication (SOLO) or despite a stabilized, single tablet, triple, fixed dose antihypertensive treatment regimen (TRIO).
Ajay J. Kirtane, MD, SM, is Professor of Medicine at Columbia University Irving Medical Center and Director of the Cardiac Catheterization Laboratories at NewYork-Presbyterian/Columbia University Irving Medical Center. Dr. Kirtane is an internationally-renowned leader in Interventional Cardiology, specializing in the care of patients with complex coronary and peripheral vascular disease. In this video, he speaks about A Study of the ReCor Medical Paradise System in Clinical Hypertension (RADIANCE-HTN).
A Summary Synopsis:
RADIANCE-HTN is a two-cohort, randomized, double-blind, sham-controlled study (TRIO and SOLO) that aims to demonstrate the efficacy and document the safety of the Paradise Renal Denervation System in two hypertensive populations.
In-depth description:
The RADIANCE Solo cohort will consist of subjects with essential hypertension who are controlled on one or two antihypertensive medications or who are uncontrolled on 0-2 antihypertensive medications, whereas the RADIANCE Trio cohort will consist of subjects with treatment resistant hypertension who are on at least three antihypertensive medications. Before randomization, subjects will be hypertensive in the absence of hypertension medication (SOLO) or despite a stabilized, single tablet, triple, fixed dose antihypertensive treatment regimen (TRIO).
Dr. Quyyumi is a tenured Professor of Medicine in Emory University School of Medicine's Division of Cardiology and Director of the Emory Clinical Cardiovascular Research Institute. In this video Dr. Quyyumi discusses the Effects of a Health‐Partner Intervention on Cardiovascular Risk.
Link to Abstract-
https://www.ahajournals.org/doi/10.1161/JAHA.116.004217
Background
Lifestyle changes are the first line of defense against cardiovascular disease. It's less apparent whether a healthy lifestyle can also help with cardiovascular health. Our research looked at the impact of a lifestyle intervention provided by a Health Partner on indicators of optimum cardiovascular health.
Results and Methods
At Emory University, 711 university employees (4811 years old; 66 percent women, 72 percent Caucasian/22.5 percent African Americans) participated in a program promoting healthy living (Atlanta, GA). At baseline, 6 months, 1 year, and 2 years after that, anthropometric, laboratory, and physical activity measurements were taken. The Health Partner used the results to create a customised plan aimed at achieving ideal health metrics. At the 6-month, 1-year, and 2-year follow-up visits, systolic blood pressure was lower by 3.6, 4.6, and 3.3 mm Hg (P0.001), total cholesterol was lower by 5.3, 6.5, and 6.4 mg/dL (P0.001), body mass index was lower by 0.33, 0.45, and 0.38 kg/m2 (P0.001), and the percentage of smokers was lower by 1.3 percent, 3.5 percent, and 3.5 percent The changes were more pronounced in those who had more anomalies at the start. Finally, compared to the baseline visit, the American Heart Association "Life's Simple 7" ideal cardiovascular health score increased by 0.28, 0.40, and 0.33 at 6 months, 1 year, and 2 years.
Conclusions
A personalized, goal-directed Health Partner intervention reduced the cardiometabolic risk profile and cardiovascular health measures dramatically. These effects were visible six months after enrollment and lasted for two years. More research is needed to see if the Health Partner intervention reduces long-term morbidity and mortality while remaining cost-effective. /
Luis M. Ruilope is a professor at the Autonoma University's Department of Public Health and Preventive Medicine and the director of the Instituto de Investigación 12 de Octubre's Cardiovascular and Renal Risk, both in Madrid, Spain. His main areas of interest include hypertension and cardiovascular risk. In this video Dr. Ruilope speaks on Digital therapeutics and lifestyle.
Link to Abstract-
https://academic.oup.com/eurheartj/article/42/40/4123/6377082
Hypertension, defined as a clinic blood pressure (BP) of less than 140/90 mmHg according to the most recent European [European Society of Cardiology (ESC)/European Society of Hypertension (ESH)] guidelines1, affects nearly a third of adults worldwide, and it is still one of the leading causes of premature death. 2
The 'westernized way of life,' which is characterized not only by physical inactivity and unhealthy dietary habits, which have resulted in a true pandemic of overweight/obesity, but also by frequent disruption of circadian rhythms with poor sleep patterns and high levels of psychosocial stress, is likely to increase the prevalence of hypertension in the years ahead.
3 In contrast, 'non-westernized' populations (e.g., hunter–gatherers like the Hadza, or foragers–horticulturists like the Tsimané or Yanomani) who continue to live in ways that are similar to those that have characterized human evolution (with high levels of daily physical activity and sleep–wake cycles corresponding to natural dark–light exposure, among other things) have a very low prevalence of hypertension, with virtually no evidence of age-related 3 The ESC/ESH guidelines, on the other hand, consider an optimal lifestyle (i.e. 150–300 minutes of moderate–vigorous physical activity per week, dynamic resistance such as lifting weights two–three times per week, increased consumption of vegetables, fresh fruits, fish, nuts, and unsaturated fatty acids, sodium intake 2000 mg/day, maintaining a body mass index of 20–25 kg/m2, moderate alcohol intake, and avoiding smoking) to be the only treatment needed for people with mild 1 Indeed, prescribing antihypertensive medicines at the outset has no effect on the incidence of CVD or death in people with moderate hypertension who are at low risk, and may potentially increase the risk of adverse events (e.g. hypotension, electrolyte abnormalities, or acute kidney injury). 4
In fact, there is strong evidence that living a healthy lifestyle can help prevent or control hypertension.
3 For example, a network meta-analysis (n = 39 742 participants) indicated that exercise programs and antihypertensive medication were equally beneficial in lowering blood pressure in people with hypertension.
5 There is also strong evidence for body weight reductions back to normal values in people who are overweight or obese,6 sodium restriction in people who have been diagnosed with hypertension,7 and the Dietary Approaches to Stop Hypertension (DASH) diet in people who have pre-hypertension or hypertension.
8 Furthermore, while more study is needed, accumulating evidence supports the use of less "traditional" techniques, such as circadian entrainment and stress management strategies, notwithstanding the need for more research. 3
The molecular processes explaining the effects of lifestyle intervention against hypertension are multisystemic, in contrast to the many antihypertensive medications. Preventing obesity and insulin resistance, improving vascular health—through improved redox and inflammatory status, or a healthy pattern of vessel remodelling in those who exercise regularly (i.e. an increase in the luminal diameter of conduit and resistance arteries, as well as the capillary density of skeletal muscle tissue)—and reducing sympathetic nervous system overactivity are just a few examples (SNS). 3 Regular exercise can also help to lower blood pressure through 'non-traditional' mechanisms, such as the release of muscle-derived factors (usually, but not always, small peptides) known as'myokines,' which are produced in the exercise environment and can travel through the bloodstream to induce a variety of beneficial effects, such as reduced inflammation or vasorelaxation. 9
However, in our modern communities, one of the primary issues with lifestyle modifications is sustainability. The effects of exercise intervention to lower blood pressure in young individuals with pre-hypertension/hypertension are lost after 12 months, according to meta-analytical evidence. 10 Similarly, a recent network meta-analysis indicated that while varied diets result in considerable weight and blood pressure reductions after 6 months, there are essentially no advantages beyond 12 months. 11 How can we effectively increase Westerners' adherence to healthy lifestyle interventions? One option is to exploit the present over-reliance on cellphones and other devices as a health tool. A new notion of personalised medical follow-up (dubbed "mHealth"), along with efforts by companies like Google and Apple to make their devices into mobile health centers, might usher in a new era in medicine. Another initiative along these lines is 'Digital therapeutics,' which aims to make disease management easier by encouraging people to make lifestyle changes. Despite the fast increasing availability of mobile technology aimed at improving blood pressure management, scientific evidence of their efficacy remains scarce. 12,13
The findings of HERB-DH1, a pivotal trial investigating the efficacy and safety of Digital therapeutics (a 12-week intervention followed by a 12-week follow-up) in patients with untreated essential hypertension (baseline office and ambulatory 24 h BP 140/90 mmHg and 130/80 mmHg, respectively) are reported in this issue of the European Heart Journal by Kario et al.14. HERB mobile is a new interactive smartphone software that encourages extensive lifestyle changes (such as lowering salt intake, controlling body weight, exercising, improving sleep patterns, stress coping, and limiting alcohol use) that can lead to a considerable reduction in blood pressure. Kario et al.14 developed their trial in three steps: I a lecture and advising program, followed by (ii) lifestyle interventions and (iii) self-planning and evaluation with participants, who were then encouraged to adopt the various lifestyle alterations into their lives. The intervention group showed a significant reduction in office, home, and 24-hour BP when compared to a control group that received lifestyle recommendations without the support of the mobile app, followed by improved BP control with the addition of antihypertensive medication in the second part of the study. These results were accompanied by improvements in secondary outcomes such as bigger salt intake reductions and lower body weight.
Kario et al.14's findings are intriguing and add to the body of knowledge about how to achieve adequate goals in arterial hypertension. Aside from the necessity to replicate these findings in additional cohorts, there are a few factors to consider. One is the intervention's long-term viability, with variations in blood pressure between groups marginally reduced after 24 weeks. Adherence to interventions is a crucial challenge in this regard. In this regard, participants in the study by Kario et al. showed near ideal adherence, as evidenced by a >95 percent engagement rate with the mobile app and >90 percent completion of the trial's recommendations in steps I and (ii). Future studies should show whether adherence, as well as the BP advantages, can be sustained over time. On the other hand, in order to use the app appropriately, physicians in charge must develop an adequate contact with the patient, which may constitute a time constraint. This new methodology may, in our judgment, be led by well-trained nurses. Finally, it has to be seen whether this unique method can prevent the development of sustained hypertension in persons with pre-hypertension, which would be a huge breakthrough in the area.
To effectively apply healthy lifestyle modifications for the prevention and control of arterial hypertension, more effort is required. Digital therapies, for example, could pave the way for a new era in which new millennium technology can be employed to help us return to a more "traditional" (non-westernized) way of life (Graphical Abstract).
Luis M. Ruilope is a professor at the Autonoma University's Department of Public Health and Preventive Medicine and the director of the Instituto de Investigación 12 de Octubre's Cardiovascular and Renal Risk, both in Madrid, Spain. His main areas of interest include hypertension and cardiovascular risk. In this video Dr. Ruilope speaks on Digital therapeutics and lifestyle.
Link to Abstract-
https://academic.oup.com/eurheartj/article/42/40/4123/6377082
Hypertension, defined as a clinic blood pressure (BP) of less than 140/90 mmHg according to the most recent European [European Society of Cardiology (ESC)/European Society of Hypertension (ESH)] guidelines1, affects nearly a third of adults worldwide, and it is still one of the leading causes of premature death. 2
The 'westernized way of life,' which is characterized not only by physical inactivity and unhealthy dietary habits, which have resulted in a true pandemic of overweight/obesity, but also by frequent disruption of circadian rhythms with poor sleep patterns and high levels of psychosocial stress, is likely to increase the prevalence of hypertension in the years ahead.
3 In contrast, 'non-westernized' populations (e.g., hunter–gatherers like the Hadza, or foragers–horticulturists like the Tsimané or Yanomani) who continue to live in ways that are similar to those that have characterized human evolution (with high levels of daily physical activity and sleep–wake cycles corresponding to natural dark–light exposure, among other things) have a very low prevalence of hypertension, with virtually no evidence of age-related 3 The ESC/ESH guidelines, on the other hand, consider an optimal lifestyle (i.e. 150–300 minutes of moderate–vigorous physical activity per week, dynamic resistance such as lifting weights two–three times per week, increased consumption of vegetables, fresh fruits, fish, nuts, and unsaturated fatty acids, sodium intake 2000 mg/day, maintaining a body mass index of 20–25 kg/m2, moderate alcohol intake, and avoiding smoking) to be the only treatment needed for people with mild 1 Indeed, prescribing antihypertensive medicines at the outset has no effect on the incidence of CVD or death in people with moderate hypertension who are at low risk, and may potentially increase the risk of adverse events (e.g. hypotension, electrolyte abnormalities, or acute kidney injury). 4
In fact, there is strong evidence that living a healthy lifestyle can help prevent or control hypertension.
3 For example, a network meta-analysis (n = 39 742 participants) indicated that exercise programs and antihypertensive medication were equally beneficial in lowering blood pressure in people with hypertension.
5 There is also strong evidence for body weight reductions back to normal values in people who are overweight or obese,6 sodium restriction in people who have been diagnosed with hypertension,7 and the Dietary Approaches to Stop Hypertension (DASH) diet in people who have pre-hypertension or hypertension.
8 Furthermore, while more study is needed, accumulating evidence supports the use of less "traditional" techniques, such as circadian entrainment and stress management strategies, notwithstanding the need for more research. 3
The molecular processes explaining the effects of lifestyle intervention against hypertension are multisystemic, in contrast to the many antihypertensive medications. Preventing obesity and insulin resistance, improving vascular health—through improved redox and inflammatory status, or a healthy pattern of vessel remodelling in those who exercise regularly (i.e. an increase in the luminal diameter of conduit and resistance arteries, as well as the capillary density of skeletal muscle tissue)—and reducing sympathetic nervous system overactivity are just a few examples (SNS). 3 Regular exercise can also help to lower blood pressure through 'non-traditional' mechanisms, such as the release of muscle-derived factors (usually, but not always, small peptides) known as'myokines,' which are produced in the exercise environment and can travel through the bloodstream to induce a variety of beneficial effects, such as reduced inflammation or vasorelaxation. 9
However, in our modern communities, one of the primary issues with lifestyle modifications is sustainability. The effects of exercise intervention to lower blood pressure in young individuals with pre-hypertension/hypertension are lost after 12 months, according to meta-analytical evidence. 10 Similarly, a recent network meta-analysis indicated that while varied diets result in considerable weight and blood pressure reductions after 6 months, there are essentially no advantages beyond 12 months. 11 How can we effectively increase Westerners' adherence to healthy lifestyle interventions? One option is to exploit the present over-reliance on cellphones and other devices as a health tool. A new notion of personalised medical follow-up (dubbed "mHealth"), along with efforts by companies like Google and Apple to make their devices into mobile health centers, might usher in a new era in medicine. Another initiative along these lines is 'Digital therapeutics,' which aims to make disease management easier by encouraging people to make lifestyle changes. Despite the fast increasing availability of mobile technology aimed at improving blood pressure management, scientific evidence of their efficacy remains scarce. 12,13
The findings of HERB-DH1, a pivotal trial investigating the efficacy and safety of Digital therapeutics (a 12-week intervention followed by a 12-week follow-up) in patients with untreated essential hypertension (baseline office and ambulatory 24 h BP 140/90 mmHg and 130/80 mmHg, respectively) are reported in this issue of the European Heart Journal by Kario et al.14. HERB mobile is a new interactive smartphone software that encourages extensive lifestyle changes (such as lowering salt intake, controlling body weight, exercising, improving sleep patterns, stress coping, and limiting alcohol use) that can lead to a considerable reduction in blood pressure. Kario et al.14 developed their trial in three steps: I a lecture and advising program, followed by (ii) lifestyle interventions and (iii) self-planning and evaluation with participants, who were then encouraged to adopt the various lifestyle alterations into their lives. The intervention group showed a significant reduction in office, home, and 24-hour BP when compared to a control group that received lifestyle recommendations without the support of the mobile app, followed by improved BP control with the addition of antihypertensive medication in the second part of the study. These results were accompanied by improvements in secondary outcomes such as bigger salt intake reductions and lower body weight.
Kario et al.14's findings are intriguing and add to the body of knowledge about how to achieve adequate goals in arterial hypertension. Aside from the necessity to replicate these findings in additional cohorts, there are a few factors to consider. One is the intervention's long-term viability, with variations in blood pressure between groups marginally reduced after 24 weeks. Adherence to interventions is a crucial challenge in this regard. In this regard, participants in the study by Kario et al. showed near ideal adherence, as evidenced by a >95 percent engagement rate with the mobile app and >90 percent completion of the trial's recommendations in steps I and (ii). Future studies should show whether adherence, as well as the BP advantages, can be sustained over time. On the other hand, in order to use the app appropriately, physicians in charge must develop an adequate contact with the patient, which may constitute a time constraint. This new methodology may, in our judgment, be led by well-trained nurses. Finally, it has to be seen whether this unique method can prevent the development of sustained hypertension in persons with pre-hypertension, which would be a huge breakthrough in the area.
To effectively apply healthy lifestyle modifications for the prevention and control of arterial hypertension, more effort is required. Digital therapies, for example, could pave the way for a new era in which new millennium technology can be employed to help us return to a more "traditional" (non-westernized) way of life (Graphical Abstract).
New Approaches to Illuminate the Pathobiology of Pulmonary Hypertension
Sammy Zakaria, MD, MPH from Johns Hopkins University speaks about Acute Cardiac Effects of Severe Pre-Eclampsia.
Link to Article:
https://www.jacc.org/doi/10.1016/j.jacc.2018.04.048
Summary
Background: Pre-eclampsia with severe features (PEC) is a pregnancy-related condition marked by severe hypertension and end-organ dysfunction, as well as short-term adverse cardiovascular events such as heart failure, pulmonary edema, and stroke.
Objectives include:
The authors wanted to see how right ventricular (RV) systolic pressure (RVSP) and echocardiographic-derived diastolic, systolic, and speckle monitoring parameters changed over time in women with PEC.
Methodologies:
The authors enrolled 63 women with PEC and 36 pregnant control patients in this prospective retrospective study.
The following are the outcomes:
As compared to the control cohort, the PEC cohort had a higher RVSP (31.0 7.9 mm Hg vs. 22.5 6.1 mm Hg; p 0.001) and a lower global RV longitudinal systolic strain (RVLSS) (19.6 3.2 percent vs. 23.8 2.9 percent [p 0.0001]). There were significant differences (p 0.001) in mitral septal e′ velocity (9.6 2.4 cm/s vs. 11.6 1.9 cm/s), septal E/e′ ratio (10.8 2.8 vs. 7.4 1.6), left atrial area size (20.1 3.8 cm2 vs. 17.3 2.9 cm2), and posterior and septal wall thickness for left-sided cardiac parameters (median [interquartile range]: 1.0 cm [0.9 to 1.1 cm] vs. 0.8 cm [0.7 to 0.9 cm], and 1.0 cm [0.8 to 1.2 cm] vs. 0.8 cm [0.7 to 0.9 cm]). PEC was seen in eight women (12.7%) with grade II diastolic dysfunction and six women (9.5%) with peripartum pulmonary edema.
Final Thoughts:
When compared to healthy pregnant women, women with PEC have higher RVSP, higher rates of irregular diastolic activity, decreased global RVLSS, increased left-sided chamber remodeling, and higher rates of peripartum pulmonary edema.
Rozh H. Al-Mashhadi, MD from the Aarhus University Hospital discusses Local Pressure Drives Low-Density Lipoprotein Accumulation and Coronary Atherosclerosis in Hypertensive Minipigs.
Link to Research -
https://www.jacc.org/doi/10.1016/j.jacc.2020.11.059?utm_medium=social&utm_source=twitter_post&utm_campaign=twitter_post
Instract
Context
There is a limited understanding of the mechanisms by which hypertension accelerates coronary artery disease. There are sometimes confusing humoral changes in patients with hypertension, and to date, no experimental models have allowed the isolated effect of pressure on atherosclerosis to be studied in a setting that recapitulates the dimensions and biomechanics of human coronary arteries.
Targets
This thesis aimed to examine and explore the fundamental mechanisms of the impact of pressure on coronary atherosclerosis.
Methodology
Using inflatable suprarenal aortic cuffs, in the cephalad body portion of wild-type and hypercholesterolemic proprotein convertase subtilisin kexin type 9 (PCSK9)D374Y Yucatan minipigs, we increased mean arterial pressure by >30 mm Hg for >1 year. Pressures at the caudal remained natural.
Outcomes
Cephalad hypertension accelerated coronary atherosclerosis to nearly 5-fold under hypercholesterolemic conditions in transgenic PCSK9D374Y mini pigs, with the consistent development of fibroatheromas that were sufficiently large to induce computed tomography angiography stenosis. This was caused by local pressure forces since there were no changes in lesion formation in vascular beds shielded from hypertension but subjected to the same humoral influences. The same experiment was performed to investigate the underlying mechanisms under normocholesterolemic conditions in wild-type mini-pigs. Hypertension with increased abundance of mechanical strength proteins and decreased levels of infiltrating plasma macromolecules induced clear changes in the arterial proteome. Increased smooth muscle cells and increased intimate accumulation of low-density lipoproteins in the coronary arteries were parallel to this.
Findings
Coronary atherosclerosis is facilitated by elevated pressure per se. Our data show that redesign of the artery to balance higher tensile forces in hypertension changes the movement of macromolecules and contributes to the increased intimate accumulation of lipoproteins of low density.