Myocardial Infarction - Myocardial Infarction - 774 · myocardial-infarction
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Prakriti Gaba, MD @PrakritiGaba @DLBHATTMD @BrighamWomens @HarvardMed #REDUCEIT #CardioTwitter Phase 3 REDUCE-IT Trial Prakriti Gaba, MD @PrakritiGaba @DLBHATTMD @BrighamWomens @HarvardMed #REDUCEIT #CardioTwitter Phase 3 REDUCE-IT Trial
0:07:11

Prakriti Gaba, MD @PrakritiGaba @DLBHATTMD @BrighamWomens...

Prakriti Gaba, MD, Cardiology Fellow at Harvard Medical School. In this video, she speaks about the Prevention of Cardiovascular Events and Mortality With Icosapent Ethyl in Patients With Prior Myocardial Infarction.

 

Outline

 

Origins:

 

REDUCE-IT was a double-blind experiment in which 8,179 statin-treated individuals with reduced low-density lipoprotein cholesterol and moderately increased triglycerides were randomly assigned to icosapent ethyl (IPE) or placebo. The primary objective, including death from cardiovascular (CV) causes, was significantly reduced. It was uncertain what effect IPE has on people who had previously had a myocardial infarction (MI).

 

Goals:

 

In REDUCE-IT, we wanted to look at the effect of IPE on ischemic events in patients who had previously had a MI.

 

Methodology:

 

We conducted post-hoc analysis on patients who had previously experienced MI. CV mortality, MI, stroke, coronary revascularization, or hospitalization for unstable angina were the primary endpoints. The most important secondary outcome was CV death, MI, or stroke.

 

Outcomes:

 

A total of 3,693 patients had a previous MI. With IPE vs placebo, the primary endpoint was lowered from 26.1 percent to 20.2 percent; HR: 0.74 (95 percent CI: 0.65-0.85; P = 0.00001). The main secondary endpoint was lowered from 18.0% to 13.3%; HR: 0.71 (95 percent CI: 0.61-0.84; P = 0.00006). There was also a substantial 35% relative risk reduction in total ischemia events (P = 0.0000001), 34% reduction in MI (P = 0.00009), 30% reduction in CV death (P = 0.01), and a 20% reduction in all-cause mortality (P = 0.054), despite a modest rise in atrial fibrillation. Sudden cardiac death and cardiac arrest were also drastically reduced by 40% and 56%, respectively.

 

Inferences:

 

Patients in REDUCE-IT with a history of recent MI who were treated with IPE had large and significant relative and absolute risk reductions in ischemic events, including CV mortality. (AMR101 Study to Assess Its Ability to Reduce Cardiovascular Events in High-Risk Patients With Hypertriglyceridemia and Statin Use. The primary goal is to assess the effect of 4 g/day AMR101 on the occurrence of a first major cardiovascular event. NCT01492361; [REDUCE-IT])

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Myocardial Infarction Description
Myocardial Infarction

Podcast Prakriti Gaba, MD @PrakritiGaba @DLBHATTMD @BrighamWomens @HarvardMed #REDUCEIT #CardioTwitter Phase 3 REDUCE-IT Trial
0:07:11
Podcast Prakriti Gaba, MD @PrakritiGaba @DLBHATTMD @Brigh...
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Prakriti Gaba, MD @PrakritiGaba @DLBHATTMD @BrighamWomens @HarvardMed #REDUCEIT #CardioTwitter Phase 3 REDUCE-IT Trial Prakriti Gaba, MD @PrakritiGaba @DLBHATTMD @BrighamWomens @HarvardMed #REDUCEIT #CardioTwitter Phase 3 REDUCE-IT Trial
0:07:11
Prakriti Gaba, MD @PrakritiGaba @DLBHATTMD @BrighamWomens...
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Podcast Allan S. Jaffe, MD @MayoClinicCV @MayoClinic #MI #CABG Revisiting The Definition PMI After CABG
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Podcast Allan S. Jaffe, MD @MayoClinicCV @MayoClinic #MI ...
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Allan S. Jaffe, MD @MayoClinicCV @MayoClinic #MI #CABG Revisiting The Definition PMI After CABG Allan S. Jaffe, MD @MayoClinicCV @MayoClinic #MI #CABG Revisiting The Definition PMI After CABG
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Allan S. Jaffe, MD @MayoClinicCV @MayoClinic #MI #CABG Re...
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Podcast- Dr. Jung-Joon Cha, MD- Clinical Outcomes in Patients With Delayed Hospitalization for Non–ST-Segment Elevation Myocardial Infarction  #MyocardialInfarction #Cardiology #Research
0:13:51
Podcast- Dr. Jung-Joon Cha, MD- Clinical Outcomes in Pati...
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Dr. Jung-Joon Cha, MD- Clinical Outcomes in Patients With Delayed Hospitalization for Non–ST-Segment Elevation Myocardial Infarction  #MyocardialInfarction #Cardiology #Research Dr. Jung-Joon Cha, MD- Clinical Outcomes in Patients With Delayed Hospitalization for Non–ST-Segment Elevation Myocardial Infarction  #MyocardialInfarction #Cardiology #Research
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Dr. Jung-Joon Cha, MD- Clinical Outcomes in Patients With...
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Podcast- Antonio Abbate, MD & Ben Van Tassell, PharmD - Interleukin-1 (IL-1) Blockade in Acute Myocardial Infarction (VCU-ART3) @AbbateAntonio   @bvantassell  #VCUART3Trial #MyocardialInf...
0:15:05
Podcast- Antonio Abbate, MD & Ben Van Tassell, PharmD - I...
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Antonio Abbate, MD & Ben Van Tassell, PharmD - Interleukin-1 (IL-1) Blockade in Acute Myocardial Infarction (VCU-ART3) (VCU-ART3) @AbbateAntonio   @bvantassell  #VCUART3Trial #MyocardialI... Antonio Abbate, MD & Ben Van Tassell, PharmD - Interleukin-1 (IL-1) Blockade in Acute Myocardial Infarction (VCU-ART3) (VCU-ART3) @AbbateAntonio   @bvantassell  #VCUART3Trial #MyocardialI...
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Antonio Abbate, MD & Ben Van Tassell, PharmD - Interleuki...
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Dr. Mia Ravn Jacobsen, M.D. -@Rigshospitalet @uni_copenhagen @AalborgUH #MyocardialInfraction #Cardiology #Research  Clopidogrel, prasugrel, and ticagrelor for all-comers with ST-segment ...
0:13:34
Dr. Mia Ravn Jacobsen, M.D. -@Rigshospitalet @uni_copenha...
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Dr. Mia Ravn Jacobsen, M.D. -@Rigshospitalet @uni_copenhagen @AalborgUH #MyocardialInfraction #Cardiology #Research  Clopidogrel, prasugrel, and ticagrelor for all-comers with ST-segment ... Dr. Mia Ravn Jacobsen, M.D. -@Rigshospitalet @uni_copenhagen @AalborgUH #MyocardialInfraction #Cardiology #Research  Clopidogrel, prasugrel, and ticagrelor for all-comers with ST-segment ...
0:13:34
Dr. Mia Ravn Jacobsen, M.D. -@Rigshospitalet @uni_copenha...
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Jeffrey J. Goldberger, MD @DrJGoldberger @UMiamiHealth #OBTAINRegistry #MyocardialInfarction #Cardiology #Heart #Research Comparison of Metoprolol versus Carvedilol After Acute Myocardial... Jeffrey J. Goldberger, MD @DrJGoldberger @UMiamiHealth #OBTAINRegistry #MyocardialInfarction #Cardiology #Heart #Research Comparison of Metoprolol versus Carvedilol After Acute Myocardial...
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Jeffrey J. Goldberger, MD @DrJGoldberger @UMiamiHealth #O...
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Khaled Ziada, MD @ZiadaK @ClevelandClinic #Myocardial Infarction #Cardiology #Research Cangrelor in ST-Elevation Myocardial Infarction to Decrease Infarct Size Khaled Ziada, MD @ZiadaK @ClevelandClinic #Myocardial Infarction #Cardiology #Research Cangrelor in ST-Elevation Myocardial Infarction to Decrease Infarct Size
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Khaled Ziada, MD @ZiadaK @ClevelandClinic #Myocardial Inf...
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