Prevention - Prevention - 379 · prevention
    • CardiologyTalk

      Site: CardiologyTalk

    • Quick Links
      • Schedule An Interview
      • What Is Our Interview Process
    • 0
      • Portuguese
      • Spanish
      • Italian
      • Greek (Greece)
      • Sinhala
      • Polish
      • Arabic (Saudi Arabia)
      • Swedish (Sweden)
      • Portuguese (Brazil)
      • Hindi (India)
      • English (Australia)
      • Hebrew (Israel)
      • Czech
      • Hungarian (Hungary)
      • Chinese
      • Turkish
      • Japanese (Japan)
      • Dutch
      • French
      • German
      • Chinese (Traditional Han, Taiwan)
      • Korean (South Korea)
      • Thai
      • Spanish (Chile)
      • English (United States)
      • Russian
      • Danish (Denmark)
  • Home
  • Trending

  • Login

  • Audio and Video
  • Videos
  • Audio

  • Channels
  • Browse Channels

  • Categories
  • Acute Pulmonary Embolism 1
  • Amyloidosis 10
  • Angina 1
  • Anticoagulation Management 1
  • Aortic Stenosis 1
  • Arrhythmias and Clinical EP 2
  • Atrial Fibrillation 18
  • Autonomic Cardiology 1
  • Blood Pressure 1
  • Cardiac Implantable Electronic Devices 2
  • Cardiac Injury 3
  • Cardiac Surgery 13
  • Cardio-Oncology 17
  • Cardiogenic Shock 4
  • Cardiology 111
  • Cardiology Advocacy 16
  • Cardiomyopathy 5
  • Cardiorenal 2
  • Cardiorenal Syndrome 1
  • Cardiovascular Disease 17
  • Cardiovascular Imaging 2
  • Conference Coverage 63
  • Congenital Heart Disease 1
  • Coronary Artery Disease 11
  • Coronary Microvascular Dysfunction 3
  • Coronary Pharmacotherapy 1
  • Coronary Stent 2
  • COVID-19 81
  • Diabeto-Cardiology 2
  • Dyslipidemia 1
  • Echocardiograms 3
  • Heart Disease 1
  • Heart Failure and Cardiomyopathies 60
  • Heart Transplant 1
  • Heart Valve 3
  • Hemostasis 1
  • Hypertension 12
  • Hypertrophic Cardiomyopathy 2
  • Irregular Heart Rhythm 1
  • Ischemic Heart Disease 4
  • Myocardial Infarction 13
  • Prevention 4
  • Pulmonary Hypertension 2
  • Stroke 1
  • Structural Heart Disease 1
  • TAVR 3
  • Transcatheter Aortic Valve (TAVI) 3
  • Tricuspid Regurgitation 1
  • Valvular Heart Disease 2
  • Vasovagal Syncope 1
  • Ventricular Failure 1
  • Acute Coronary Syndromes 189

  • Install
  • Play a Link
  • About
  • Contact
Rohan Khera, MD, MS @rohan_khera @YaleMed @YaleCardiology @cards_lab #ASSIST #ChestPain #Cardiology #Research A phenomapping-derived tool to personalize the selection of anatomical vs. fu... Rohan Khera, MD, MS @rohan_khera @YaleMed @YaleCardiology @cards_lab #ASSIST #ChestPain #Cardiology #Research A phenomapping-derived tool to personalize the selection of anatomical vs. fu...
0:05:56

Rohan Khera, MD, MS @rohan_khera @YaleMed @YaleCardiology...

Rohan Khera, MD, MS, Assistant Professor at Yale School of Medicine speaks about A phenomapping-derived tool to personalize the selection of anatomical vs. functional testing in evaluating chest pain (ASSIST).

Link to Lab's ASSIST:
https://www.cards-lab.org/assist

Link to Article:
https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehab223/6242724?utm_medium=Email&utm_source=My%20ESC%20News&utm_campaign=ESC+-+Newsletter+-+week+17+-+2021

Summary

Objectives

Coronary artery disease is often identified after anatomical or clinical examination is used to evaluate persistent chest pain. Personalized testing could be possible with a more detailed knowledge of patient phenotypes that benefit from either approach.


Methods and outcomes

We generated a topological representation of the sample population based on 57 pre-randomization variables using participant-level results from 9572 patients undergoing anatomical (n = 4734) vs. functional (n = 4838) research in the PROMISE (PROspective Multicenter Imaging Study for Evaluation of Chest Pain) trial. Cox regression models presented individual patient-centered hazard ratios for significant adverse cardiovascular outcomes within each patient's 5% topological neighbourhood and showed marked heterogeneity around the phenomap [median 1.11 (10th to 90th percentile: 0.52–2.61]], suggesting distinct phenotypic neighbourhoods favoring anatomical or functional research. We used an intense gradient boosting algorithm in 80% of the PROMISE population to estimate the personalized value of anatomical vs. functional tests using 12 model-derived, regularly collected variables and generated a decision support method called ASSIST based on this vulnerability phenomap (Anatomical vs. Stress teSting decIsion Support Tool). The testing strategy recommended by ASSIST was associated with a significantly lower incidence of each study's primary endpoint in both the remaining 20% of PROMISE and an external validation set consisting of patients from SCOT-HEART (Scottish COmputed Tomography of the HEART Trial) undergoing anatomical-first vs. functional-first assessment (P = 0.0024 and P = 0.0321 for interaction, respectively) in both the remaining 20% of PROMISE and an external validation set consist

Final thoughts

We suggest a new phenomapping-based decision support method to standardize the use of structural vs. functional research in the treatment of controlled chest pain, which has been tested in two broad and geographically disparate clinical trial populations.

128 Views
1 year Ago
Cardiology News
Add to
Want to watch this again later?
Sign in to add this video to a playlist. Login

Prevention Description
Prevention

Preventive Cardiovascular Medicine through a 20/20 Lens
01:09:29
Preventive Cardiovascular Medicine through a 20/20 Lens
3 Views
1 year Ago
Yale Cardiovascular Medicine Grand Rounds
Add to
Want to watch this again later?
Sign in to add this video to a playlist. Login
Rohan Khera, MD, MS @rohan_khera @YaleMed @YaleCardiology @cards_lab #ASSIST #ChestPain #Cardiology #Research A phenomapping-derived tool to personalize the selection of anatomical vs. fu... Rohan Khera, MD, MS @rohan_khera @YaleMed @YaleCardiology @cards_lab #ASSIST #ChestPain #Cardiology #Research A phenomapping-derived tool to personalize the selection of anatomical vs. fu...
0:05:56
Rohan Khera, MD, MS @rohan_khera @YaleMed @YaleCardiology...
FHD
128 Views
1 year Ago
Cardiology News
Add to
Want to watch this again later?
Sign in to add this video to a playlist. Login
#17 Inpatient HFrEF & HFpEF management with Carolyn Lam MBBS PhD #17 Inpatient HFrEF & HFpEF management with Carolyn Lam MBBS PhD
0:43:14
#17 Inpatient HFrEF & HFpEF management with Carolyn Lam M...
HD
13 Views
2 years Ago
HeartSuccess
Add to
Want to watch this again later?
Sign in to add this video to a playlist. Login
Top 10 Reasons to Onboard to Heartbeat Health
00:03:23
Top 10 Reasons to Onboard to Heartbeat Health
12 Views
2 years Ago
American College of Cardiology
Add to
Want to watch this again later?
Sign in to add this video to a playlist. Login

CardiologyTalk Copyright 2020