Laura M. Stevens, Ph.D. @CUMedicalSchool @CUAnschutz @CU_MSTP @American_Heart #HeartFailure #Cardiology #Research Ass...

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Laura M. Stevens, Ph.D. from the Computational Bioscience Program, Department of Pharmacology (L.M.S.), University of Colorado Anschutz Medical School, Aurora and The American Heart Association discusses Association Between Coffee Intake and Incident Heart Failure Risk.

Link to Abstract -

Abstract -


Complex diseases with different phenotypes include coronary heart disease, heart failure (HF), and stroke. While several risk factors are well known for these diseases, researching as-yet unidentified risk factors will enhance risk evaluation and adherence to patients to preventive guidelines. In the FHS (Framingham Heart Study), CHS (Cardiovascular Heart Study), and ARIC (Atherosclerosis Risk in Communities) study, we investigated the diet domain to identify possible lifestyle and behavioral factors associated with coronary heart disease, HF, and stroke.


To classify possible risk factors associated with coronary heart disease, stroke, and HF in FHS, we used machine learning feature selection based on random forest analysis. Using univariable and multivariable Cox proportional hazards analysis optimized for known cardiovascular dangers, we assessed the importance of selected variables. Using CHS and ARIC, findings from FHS were then confirmed.


Multiple dietary and behavioral risk factors for cardiovascular disease outcomes were reported, including marital status, consumption of red meat, consumption of whole milk, and consumption of coffee. Among these dietary variables, the increase in coffee intake in FHS, ARIC, and CHS was associated with a decrease in the long-term risk of HF.

In all three studies, higher coffee intake was found to be associated with reduced HF risk. In order to better define the function, potential causality, and potential mechanism of coffee consumption as a potentially modifiable risk factor for HF, further research is warranted.